Prevention, control and treatment of BRD in the beef and dairy herd

It doesn’t matter what you call it

Whether you call it pneumonia in calves or shipping fever in cattle, the effects of bovine respiratory disease (BRD) are equally detrimental to a calf’s respiratory system. BRD in cattle is often the result of environmental stressors causing bacteria to accumulate in the lungs.

BRD sets back beef and dairy operations

Pneumonia in calves is one of the biggest threats to beef and dairy operations today. It’s estimated that pneumonia in cattle costs producers up to $15 per calf per year, and the disease often results in the death of cattle if not caught in time.1

Replacement heifers can suffer lifetime consequences

This can have big implications for replacement heifers. Even beef and dairy cows that have recovered from BRD can have growth, fertility and milk production deficits for life. That’s why it’s important to treat and control BRD in its earliest stages, and the way to do so is with ZACTRAN® (gamithromycin).

Why ZACTRAN is the smart solution

ZACTRAN is a fast acting cattle antibiotic indicated for bovine respiratory disease (BRD) treatment and control.4

Rapidly absorbed

Gamithromycin, the active ingredient in ZACTRAN, is rapidly absorbed and distributed in lung tissue.2 3*

*Clinical relevance has not been determined.

Effective and economical

A single injection provides 10-day BRD treatment and control that’s both effective and economical.3  In trials, ZACTRAN significantly reduced the loss associated with BRD in cattle stressed from shipping, processing and commingling.4


Merial is now a part of Boehringer Ingelheim. ®ZACTRAN is a registered trademark of Merial. ©2017 Merial, Inc., Duluth, GA. All rights reserved. RUMIOTD1716 (1/17)

1Shelton T. The next step in BRD management. Progressive Dairyman. 2012. Available at: tion=com_content&view=article&id=8623:the- next-step-in-brd-management&catid=45:herd- health&Itemid=71. Accessed October 4, 2012.

2Huang RA, Letendre LT, Banav N, et al. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J Vet Pharmacol Ther. 2010;33(3):227-237.

3ZACTRAN product label.

4Sifferman RL, Wolff WA, Holste JE, et al. Field efficacy evaluation of gamithromycin for treatment of bovine respiratory disease in cattle at feedlots. Intern J Appl Res Vet Med. 2011;9(2):171-180.

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