Bottom Line: ZACTRAN® (gamithromycin) Stops BRD From Hitting Yours.

BRD is waiting for an opportunity

Bovine respiratory disease (BRD), commonly known as shipping fever or pneumonia, is a serious condition for beef and dairy producers. In the beef industry, BRD accounts for 75% of feedlot sickness, up to 70% of feedlot deaths and $900 million in annual losses.1-4 As for dairy heifers, BRD accounts for 22.5% of deaths in pre-weaned dairy heifers, 46.5% of deaths in weaned dairy heifers and long-term performance losses.5-9

During weaning, calves are faced with many stressors. This stress can cause immunosuppression in a calf, decreasing its ability to respond to disease-causing pathogens and vaccines, making it even more susceptible to BRD.

And once calves are affected by BRD, there are both immediate and long-lasting effects on health and performance. But you can manage the risk with ZACTRAN. A single administration provides 10-day BRD treatment and control.

How BRD Occurs

Bovine respiratory disease numbered bacteria flow within cattle.

1. BRD bacteria reside in the upper respiratory tract of all cattle, even healthy animals.

2. Viral infections and stress from shipping, weaning and other events allow bacteria to accumulate in the lungs.

3. Bacteria colonize and proliferate, causing inflammation, leading to BRD or shipping fever.



ZACTRAN treats all major BRD-causing bacteria.

Bovine respiratory disease often involves more that one bacterial pathogen, these pathogens are sensitive to gamithromycin, the active ingredient in Zactran.

ZACTRAN is indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis.10


ZACTRAN starts killing BRD-causing bacteria within 30 minutes.11*

With Zactran, you should start to see improvement in sick cattle the next day.

After you administer ZACTRAN, the broad-spectrum antibiotic rapidly reaches the site of infection — the lungs — where it kills bacteria and stops them from replicating.

*Clinical relevance has not been determined.


With ZACTRAN, you typically see improvement within 24 hours.12**

Zactran can be used with automatic syringes and offers a low dose volume.

In a study, cattle treated with ZACTRAN responded within 24 hours. Cattle had lower temperatures, were more alert and were breathing easier.11

**A small percentage of cattle may have already suffered lung damage, and may be too far gone or will require a little longer to turn around.


It provides 10 days of therapy from a single injection.10

Zactran gives the animal's immune system 10 days to fight off bovine respiratory disease.

ZACTRAN keeps working for 10 days, reducing the time and labor associated with repulls. With less handling, cattle experience less stress — so they can focus on gaining weight.


Treat cattle with one cost-effective dose.

Economically managing bovine respiratory disease, with Zactran, is critical to maintaining a profitable herd.

ZACTRAN is competitively priced, and a single dose goes a long way, providing 10 days of BRD treatment or control.

The ZACTRAN Advantage

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