Make ZACTRAN your choice for BRD treatment and control.

Zactran is the smart choice for cattle for bovine respiratory disease treatment.

Why ZACTRAN is the smart choice

ZACTRAN is a novel subclass of macrolide with a structural difference.55 - Data on file at Merial. ZACTRAN is a 15-membered dibasic macrolide from the 7a-azalide subclass. The unique structure of gamithromycin, the active ingredient in ZACTRAN, results in rapid, extensive distribution throughout the lungs and ≥95% bioavailability following subcutaneous (SC) injection.77 - Huang RA, Letendre LT, Banav N, et al. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J Vet Pharmacol Ther. 2010;33(3):227-237.* ZACTRAN reaches levels above MIC90 for common bacterial BRD pathogens in lung tissue within 30 minutes, remaining at high concentrations above MIC90 in lung tissue and bronchoalveolar lavage (BAL) cells for 10 days.66 - Giguere S, Huang R, Malinski TJ, et al. Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells and lung tissue in cattle. Am J Vet Res. 2011;72(3):326-330.*

*Clinical relevance has not been determined.

Rapid absorption for rapid results

  • ≥95 percent bioavailable following subcutaneous (SC) injection.77 - Huang RA, Letendre LT, Banav N, et al. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J Vet Pharmacol Ther. 2010;33(3):227-237.
  • Rapidly absorbed and extensively distributed throughout the lungs.3,73 - ZACTRAN product label.

    7 - Huang RA, Letendre LT, Banav N, et al. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J Vet Pharmacol Ther. 2010;33(3):227-237.
  • Reaches levels above MIC90 in lung tissue within 30 minutes.66 - Giguere S, Huang R, Malinski TJ, et al. Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells and lung tissue in cattle. Am J Vet Res. 2011;72(3):326-330.
  • Remains at high concentrations above MIC90 in lung tissue and bronchoalveolar lavage (BAL) cells for 10 days.66 - Giguere S, Huang R, Malinski TJ, et al. Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells and lung tissue in cattle. Am J Vet Res. 2011;72(3):326-330.
  • Exhibits both bactericidal and bacteriostatic activity: killing bacteria and stopping its growth.33 - ZACTRAN product label.

*Clinical relevance has not been determined.

ZACTRAN compares favorably to DRAXXIN® (tulathromycin), EXCEDE® (ceftiofur crystalline-free acid) and ZUPREVO (tildipirosin) for control of BRD.9,109 - Data on file at Merial.

10 - Amrine D, White B, Goehl D, Sweiger SH, Nosky B, Tessman RK. Comparisons of Metaphylactic Treatments of ZACTRAN® (gamithromyicn) vs. Excede® (ceftiofur crystalline free acid) in High Risk Stocker Calves. Intern J Appl Res Vet Med. 2014;12(3):221-228.

Zactran compares favorably to Draxxin for control of BRD.

 

  • In a 1,500-dairy heifer study across 11 operations, ZACTRAN was superior to DRAXXIN for control of BRD, and BRD with co-morbidity by otitis media.1212 - Linhart RD, Brumbaugh GW. Control of bovine respiratory disease, with and without co-morbidity by otitis media, in dairy heifers comparing gamithromycin, tulathromycin, or no medication at a commercial development facility. J Dairy Sci 2019;102(6):5501-5510.
  • ​ZACTRAN improved the first treatment rate by 15.5%.
  • For every 15 animals that received ZACTRAN, there was one less animal that required treatment because of BRD than for those that received DRAXXIN.


*Statistically significant treatment difference (P ≤ 0.05).

  • In field trials, cattle treated with ZACTRAN showed a rapid response and significant improvement in BRD clinical signs within 24 hours after treatment.44 - Sifferman RL, Wolff WA, Holste JE, et al. Field efficacy evaluation of gamithromycin for treatment of bovine respiratory disease in cattle at feedlots. Intern J Appl Res Vet Med. 2011;9(2):171-180.
  • In field trials, ZACTRAN provided 10-day treatment and control of BRD from a single dose.1111 - Lechtenberg K, Daniels CS, Royer GC, et al. Field efficacy study of gamithromycin for the control of bovine respiratory disease in cattle at high risk of developing the disease. Intern J Appl Res Vet Med. 2011;9(2):189-197.
Zactran compares favorably to Zuprevo for control of BRD.


A 2019 study evaluated the differences between ZACTRAN, DRAXXIN and ZUPREVO when used as metaphylaxis treatments to control BRD in calf-fed Holstein steers upon arrival at feedlots.1313 - Raymond RC, Buchanan JW, Nilles AR. Comparison of three injectable metaphylactic antimicrobial treatments administered at feedlot arrival for control of bovine respiratory disease in calf-fed Holstein steers. Bov Pract 2020.

ZACTRAN performed better and had the lowest overall program cost:

  • Highest first-treatment success
  • Lowest realizer rate
  • Greater number of marketable cattle with lowest total outs (realizers + mortalities)
  • Ribeye area was greatest
  • $16.65-per-head advantage to ZACTRAN versus DRAXXIN
  • $2.58-per-head advantage to ZUPREVO when accounting for metaphylaxis cost

Indications33 - ZACTRAN product label.

  • ZACTRAN is indicated for the treatment of BRD associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis in beef and non-lactating dairy cattle.
  • ZACTRAN is indicated for the control of respiratory disease in beef and non-lactating dairy cattle at high risk of developing BRD associated with M. haemolytica and P. multocida.
Zactran is competitively priced offers a low dose volume and is available by prescription only.

Easy and Economical

  • ZACTRAN is competitively priced for treatment or control of BRD in stressed cattle on arrival, and can help improve clinic profitability.
  • ZACTRAN offers a low-dose volume (2 mL/110 lbs.) and is administered subcutaneously in the easily accessible neck area.33 - ZACTRAN product label.
  • ZACTRAN is available only by prescription.
Zactran, a BRD prevention medication, versus the competition.

The ZACTRAN Advantage

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Technical Content


Comparison of Zactran® (gamithromycin) and Zuprevo (tildipirosin) for metaphylaxis treatment of winter-placed feedlot calves for control of bovine respiratory disease. The Bovine Practitioner Vol. 51, NO.2.

A randomized complete-block design trial was conducted in a commercial feedlot in Alberta, Canada using winter-placed heifer calves (n=4574; initial body weight 672 ± 43lbs) to evaluate the efficacy of metaphylactic treatment with Zactran® (gamithromycin), and Zuprevo (tildipirosin) for control of bovine respiratory disease. Read More >>